Commissioner Domzalski has served the Philadelphia Department of Public Health in numerous positions,  including Deputy Health Commissioner for Public Health Services, Director of Correctional Health, Chief of Field Operations, and District Health Director.

Elected to the Fellowship of the College of Physicians of Philadelphia in 1999, Commissioner Domzalski is also a member of the American Public Health Association, the American Bar Association and the Philadelphia Bar Association, where he co-chaired the organization's Medico-Legal Committee. Maintaining many other professional and academic affiliations, he is an Adjunct Associate Professor, School of Biomedical Engineering Science and Health Systems at Drexel University, Philadelphia, and has lectured on public health topics at other academic institutions.

A member of the City of Philadelphia Emergency Management Planning Group since 1996, Domzalski was an early advocate of bioterrorism preparedness.  He is a former president of the Prisoner's Family Welfare Association, served on the steering committee for the United States Public Health Service Bicentennial Celebration, and participated in The Presidents' Summit For America's Future.

A graduate of Bloomsburg State College, Domzalski earned his Masters in Public Health at the University of Pittsburgh and his law degree at Temple University School of Law.